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Description

Lixisenatide inhibits neuroinflammation by promoting the proteasomal degradation of thioredoxin-interacting protein (TXNIP) in ocular tissues via the PI3K/Akt signaling pathway, an effect more potent than that of insulin

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This dual-pathway activation in tirzepatide often produces stronger appetite suppression and metabolic effects, though both medications reduce hunger and improve blood sugar control

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Over 1,400 actions were pending in the MDL as of October 2024

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